细胞DNA定量分析手艺相干文献

  • 1、细胞DNA定量分析法正在宫颈癌及癌前病变筛查中的运用(第二军医大学学报 2007年6月)

    作者:蔡小兰, 侯方高

    关键字:宫颈癌,宫颈病变

    择要:

    目标:用细胞DNA定量分析要领和TBS通例细胞学要领停止宫颈癌及癌前病变筛查,以进步宫颈癌普查的准确性.要领:对停止宫颈癌普查的9 600例妇女用Autocyte prep液基薄层细胞学手艺、细胞DNA定量分析和TBS搜检要领,对宫颈病变停止晚期筛查.液基薄层制片后离别停止DNA染色和巴氏染色,对DNA染色片停止全自动细胞扫描诊断,对巴氏染色停止TBS通例细胞学诊断.效果:一切468例DNA定量分析阳性者均行阴道镜下宫颈活构造病理诊断.以病理诊断效果为尺度,细胞DNA定量分析法正在筛查CINⅡ以上宫颈病变的灵敏度为82%,而通例细胞学要领为60%.结论:正在宫颈癌及癌前病变筛查中,细胞DNA定量分析法有较高的灵敏度.


  • 2、A feasibility study of virtual slides in surgical pathology in China.(Human Pathology, 2007,38, 1842–1848)

    作者:Xinxia Li, Jianying Liu, Jiang Gu

    关键字:运用研讨

    择要:

    China's huge territorial expanse and its imbalance of regional economic development have resulted in an uneven distribution of experienced pathologists. Developing telepathology for consultation is of special relevance to China. We developed a newly designed telepathology workstation, which includes a small file size of each slide, permitting easy transmission, storage, and manipulation, and a feedback function, and also evaluated itsfeasibility in surgical pathology in China. Four hundred cases covering a broad spectrum of surgical pathology problems were investigated in a blinded fashion by the 2 pathologists using this virtual microscope system. These cases were then randomized and re-reviewed a second time with light microscope. Diagnoses and time spent for each diagnosis were recorded for both methods. The diagnostic accuracies achieved by viewing glassslides and virtual images were 97.25% (389 of 400) and 95.5% (382 of 400) for pathologist A and 96.25% (385 of 400) and 94.75% (379 of 400) for pathologist B, respectively. There was no significant diagnostic discrepancy between the 2 methods for the 2 pathologists. The average times for viewing a virtual slide were 3.41 and 5.24 minutes for pathologists A and B, respectively, whereas the average times for viewing a glass slide were 1.16 and 3.35 minutes for pathologists A and B. There was a statistical difference between the time costs of the 2 methods. However, the slight time increase using virtual slides is less than that using dynamic telepathology and traditional consultation, and is acceptable to the pathologists. These results showed that this newly designed virtual microscope system have an acceptable diagnostic accuracy that is of practical value and may be suitable for application in China.


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